Double-blinding and removing bias with over-encapsulation While there are many blinding options available, over-encapsulation remains the most popular method adopted by sponsors to meet regulatory demands due to its relative simplicity. Despite the relative simplicity of over-encapsulation, proper planning and careful execution are still fundamental to success—full consideration must be given to every detail from capsule color and size selection to having a well-trained team dedicated to the process. The most convenient capsule shell for blinding is the DBcaps® capsule. This type of shell is typically shorter and larger in diameter than the standard capsule shell sizes, making them easier for patients to swallow, helping to improve patient compliance.