Technology Selection for Bioavailability Enhancement
Due to the growing incidence of compounds with low solubility in the pharmaceutical discovery and development pipeline, the number of enabling technologies that are employed to improve oral drug absorption and bioavailability (BA) is also growing. Commonly used technologies in this area have been extensively reviewed, and include salts, cocrystals, amorphous solid dispersions, nano- and microcrystals manufactured by particle size reduction, cyclodextrin complexation, and lipid-based technologies. Selection of the proper technology can make the difference between development success or failure.
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